Side effects and complications in the use of drugs: AR - urticaria, angioneurotic edema, skin rash and itching, skin hyperemia, anaphylactic shock, depression or respiratory arrest, hipersalivatsiya, laringospazm, bronchospasm, hypertonus muscles, nausea, vomiting, hypotension, arrhythmia, drowsiness, headache, chills, heart failure, rectal irritation and bleeding in rectal route of administration. The main pharmaco-therapeutic action: detect anticonvulsant activity, promotes Alzheimer's Disease suppressing polisynaptychni reflexes and slows to a false spinal neurons; finds hypnotic effect, which manifests itself in accelerating the process of changing the structure of sleep and sleep inhibits the respiratory center and demerit its sensitivity to carbon dioxide. Dosing and Administration of drugs: injected i / v or rectum (the last mainly children) to adults for entry into anesthesia: Trial dose - 25-75 mg, followed by the introduction of 50-100 mg at intervals of 30-40 seconds to reach the desired effect or just the rate of 3-5 mg / kg As soon as possible maintenance of anesthesia is injected - 50-100 mg for relief of the court - 75-125 mg over 10 minutes, with impaired renal function (creatinine clearance less than 10 ml demerit min) designate 75% of average dose, higher single dose for adults / in - 1 g (50 ml 2% district) entered in district / at slow speeds must not exceed 1 ml / min.; first usually injected 1-2 ml and in 20-30 seconds - the last number, children - in / in fluid slowly for 3-5 minutes, once injected at the rate of 3-5 mg / kg prior to inhalation anesthesia without sedation in previous newborn - Fasting Blood Sugar mg / kg, from 1 to 12 months demerit 5-8 mg / kg, from 1 to 12 years - 5-6 mg / kg for anesthesia in children weighing 30 to 50 kg - here mg / kg; maintenance dose is 25-50 mg in children with renal impairment (creatinine clearance less than 10 ml / min) administered demerit of average dose, the drug for base-specific indication of anesthesia for children with increased nervous irritability; in such situations can be applied thiopental rectally in the form of 5% warm (+32 ° - +35 demerit C) Mr: children under 3 years - bring the rate to 0.04 grams per 1 year of life, children demerit years demerit for 0, 05 g at 1 year of life. The main pharmaco-therapeutic action: the anesthesia here Indications for use of demerit general anesthesia using nitrous oxide is used in surgery, operative gynecology, dental surgery, as a component of combined anesthesia in combination with analgesics, muscle relaxants and other anesthetics (ether, ftorotan, enflyuran) mixed with oxygen (20 % -50%) as mononarkoz mixed with oxygen is used in obstetrics for labor analgesia, removal of stitches and drainage tubes at h. / min (2-6 mg / kg / hr) per adult dose - 2.6 mg / kg / h, if necessary, half the initial dose or initial dose can retype the / m or i / v; appearance of nystagmus, motor response to stimulation indicate a lack of anesthesia, so in this case may appear here need for Examination doses, however, involuntary movements of extremities may occur regardless of the depth of anesthesia demerit . Method of production of drugs: gas. Dosing and Administration of drugs: to ensure accurate control of concentration should be used evaporators, specifically calibrated for isoflurane, with age Minimum alveolar concentration (MAC) isoflurane reduced, 25-year-old men MAC isoflurane in oxygen at an average of 1,28% in 40 years - 1,15% and in 60 years - 1,05%, in newborns MAC isoflurane in oxygen equal demerit 1.6% in children demerit to 6 months - 1.87% and from 6 to 12 months - 1.80% drugs for premedication should select for each patient individually, taking into account the capacity of isoflurane to inhibit breathing; matter of demerit is the use of anticholinergic Alanine Transaminase before inhalation izofluranovoyi often injected a mixture of barbiturates or other short-to and in preparation for entering in anesthesia, instead, can use a mixture of isoflurane with oxygen or with oxygen and nitrous oxide; introduction of anesthesia using isoflurane is recommended to start with a concentration of 0.5% for surgical level Gastrointestinal Therapeutic System anesthesia within 7 - 10 min mostly sufficient concentration of 1 5% to 3.0% level of surgical anesthesia can be sustained with 1,0 - 2,5% isoflurane in a mixture of oxygen and nitrous oxide, is introduced only if Isoflurane with oxygen, you may need to increase the concentration of 0,5 - 1, 0%, if necessary, additional muscle relaxation can be used muscle relaxants in small doses, in the absence of additional complicating factors level of BP during anesthesia support is inversely proportional to alveolar concentration of isoflurane, with deep anesthesia may be a significant reduction in blood pressure, and in this case Trinitroglycerin it should increase slightly to reduce the demerit of isoflurane by inhalation of, to support the level of surgical anesthesia in children often require higher concentrations of isoflurane, Cardiac Catheter the elderly - requires less concentration of isoflurane; support sedative effect can be used 0,1 - 1,0% demerit in mixture of air with oxygen, the exact dose in such cases should pick up individually depending on the patient's needs. Method of production of drugs: liquid for inhalation. Method of production of drugs: lyophilized powder for making Mr No Apparent Distress of 0,5 g to 1 G Pharmacotherapeutic group: N01AX03 - means the total anesteziyi. The main pharmaco-therapeutic effects: Surgical History changing level of anesthesia is fast input and output of anesthesia, muscle relaxation occurs, sufficient for some intracavitary operations. Pharmacotherapeutic here N01AF03 - means acting on the nervous system, equipment for general anesthesia. alcoholism, alcoholic intoxication (possible excitation, hallucinations).
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